Adler S P, Chandrika T, Lawrence L, Baggett J
Pediatr Infect Dis. 1983 Mar-Apr;2(2):114-8. doi: 10.1097/00006454-198303000-00009.
One hundred seventy-eight newborns were cultured for cytomegalovirus (CMV) on admission and weekly after 4 weeks of age until discharge. Eight (all with birth weights of 1050 g or less) acquired CMV while hospitalized. At least seven of the infected infants were born to CMV-seronegative mothers. The risk for seronegative infants weighing less than 1250 g of acquiring CMV was 24%. There was no correlation between duration of hospitalization and birth weight for infants hospitalized over 30 days. There was a significant correlation (P less than 0.0001) between the number of blood donors for an infant and the acquisition of CMV. Infected infants received blood from eight or more donors prior to CMV shedding. Infected low birth weight infants received blood from an average of 6.5 CMV antibody-positive donors, while uninfected low birth weight infants received blood from an average of 3.1 CMV antibody-positive donors. No infant received nonmaternal breast milk. After acquiring CMV, three infants died (only one was autopsied and had proved disseminated CMV disease), two developed hepatitis and one developed hepatosplenomegaly. These results suggest that acquired CMV infection is a significant risk to seronegative low birth weight infants who receive blood from seropositive blood donors.
178名新生儿在入院时进行了巨细胞病毒（CMV）培养，并在4周龄后每周进行一次培养，直至出院。8名（出生体重均为1050克或更低）在住院期间感染了CMV。至少7名受感染婴儿的母亲为CMV血清阴性。体重低于1250克的血清阴性婴儿感染CMV的风险为24%。住院超过30天的婴儿，住院时间与出生体重之间无相关性。婴儿的献血者数量与CMV感染之间存在显著相关性（P小于0.0001）。受感染婴儿在CMV排毒前接受了8名或更多献血者的血液。受感染的低出生体重婴儿平均接受了6.5名CMV抗体阳性献血者的血液，而未受感染的低出生体重婴儿平均接受了3.1名CMV抗体阳性献血者的血液。没有婴儿接受非母乳。感染CMV后，3名婴儿死亡（仅1名进行了尸检，证实患有播散性CMV疾病），2名患肝炎，1名患肝脾肿大。这些结果表明，获得性CMV感染对接受血清阳性献血者血液的血清阴性低出生体重婴儿构成重大风险。
