Allan J E, Shellam G R
Arch Virol. 1984;81(1-2):139-50. doi: 10.1007/BF01309303.
The course of MCMV infection was studied in a number of inbred strains of mice which differ in their resistance to the development of fatal disease induced by MCMV. Both H-2 and non-H-2 associated genes control this form of resistance and were found to influence the extent of virus replication during sublethal and severe infection. However, for a given strain the summated virus titre of the 5 organs studied was not always proportional to resistance strains. Peak titres of virus were found in the liver and spleen of each strain on days 2 to 3 during high dose infection and in resistant mice during low dose infection. Thereafter titres declined rapidly. When the proportion of the summated virus titre which was present in the spleen and liver was compared for a number of strains, variations in the growth of MCMV in the spleen were noted with 13-84 per cent of virus being found in the spleen of BALB/c, BALB.B, BALB.K and A/WySn mice and usually less than 3 per cent in the spleen of C57BL/6, C57BL/10, B10.BR, C3H and CBA mice.
在一些对巨细胞病毒（MCMV）诱导的致命疾病发展具有不同抵抗力的近交系小鼠中研究了MCMV感染过程。H-2和非H-2相关基因均控制这种抵抗力形式，并且发现在亚致死和严重感染期间它们会影响病毒复制的程度。然而，对于给定的品系，所研究的5个器官的病毒总滴度并不总是与抗性品系成比例。在高剂量感染的第2至3天，在每个品系的肝脏和脾脏中发现病毒峰值滴度，在低剂量感染时在抗性小鼠中发现病毒峰值滴度。此后滴度迅速下降。当比较多个品系脾脏和肝脏中病毒总滴度的比例时，发现MCMV在脾脏中的生长存在差异，在BALB/c、BALB.B、BALB.K和A/WySn小鼠的脾脏中发现13%-84%的病毒，而在C57BL/6、C57BL/10、B10.BR、C3H和CBA小鼠的脾脏中通常少于3%。
