Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas-Universidad Politecnica de Valencia, Avd de los Naranjos, ES-46022 Valencia, Spain.
Curr Opin Plant Biol. 2011 Oct;14(5):547-53. doi: 10.1016/j.pbi.2011.06.004.
The recent identification of abscisic acid (ABA) transporters provides an important insight into the delivery of ABA from the vascular system and its uptake by target cells. A putative connection with PYR/PYL receptors is envisaged, linking ABA uptake and intracellular perception by a fast and efficient mechanism. Downstream signaling of the core pathway involves regulation of ABA-responsive element binding factors (ABFs/AREBs) through phosphorylation, ubiquitination, and sumoylation in the case of ABI5. Several E3 ligases appear to regulate ABA signaling either positively or negatively, although relatively few targets are known yet. ABFs/AREBs are themselves subjected to transcriptional regulation, and some transcription factors (TFs) harboring the WRKY domain (WRKYs) appear to regulate their expression through W-box sequences present in the promoters of ABFs/AREBs.
最近鉴定出的脱落酸（ABA）转运蛋白为ABA 从脉管系统中的输送及其被靶细胞摄取提供了重要的见解。预计与 PYR/PYL 受体之间存在着一种假定的联系，通过快速有效的机制将 ABA 摄取和细胞内感知联系起来。核心途径的下游信号转导涉及通过磷酸化、泛素化和 SUMO 化调节 ABA 响应元件结合因子（ABFs/AREBs），在 ABI5 的情况下。几种 E3 连接酶似乎通过正调控或负调控 ABA 信号，尽管目前已知的靶标相对较少。ABFs/AREBs 本身受到转录调控，并且一些含有 WRKY 结构域的转录因子（TFs）似乎通过存在于 ABFs/AREBs 启动子中的 W-box 序列来调节它们的表达。
