Placide Ngendahayo, Robert Semoulin
Institut de Pathologie et Génétique (IPG), Gosselies, Belgium.
Int J Surg Pathol. 2012 Feb;20(1):101-4. doi: 10.1177/1066896911413577. Epub 2011 Jul 7.
Solitary fibrous tumor, initially described in the pleura, is now known to occur in various extrathoracic sites. However, its occurrence in the female genital tract, especially the vagina, is extremely rare. The authors report here a case of a well-circumscribed vaginal spindle cell nodule in a 48-year-old woman with features consistent with solitary fibrous tumor. The diagnosis was established histologically by the varying pattern with hypocellular fibrous areas alternating with hypercellular areas and hemangiopericytoma-like areas and, immunohistochemically by the strong positive reaction for CD34 and Bcl2 with a negative reaction for all other spindle cell and epithelial markers. The differential diagnosis is discussed and a review of the literature is presented.
孤立性纤维瘤最初是在胸膜中被描述的，现在已知可发生于各种胸外部位。然而，其在女性生殖道，尤其是阴道中的发生极为罕见。本文作者报告了一例48岁女性的阴道梭形细胞结节病例，其特征与孤立性纤维瘤相符。通过组织学检查，可见细胞稀少的纤维区域与细胞丰富区域以及血管外皮细胞瘤样区域交替出现的不同模式，免疫组织化学检查显示CD34和Bcl2呈强阳性反应，而所有其他梭形细胞和上皮标记物呈阴性反应，从而确立了诊断。文中讨论了鉴别诊断并对文献进行了综述。
