Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA 94118, USA.
J Gerontol B Psychol Sci Soc Sci. 2011 Jul;66 Suppl 1(Suppl 1):i102-10. doi: 10.1093/geronb/gbq071.
Early life circumstances influence health across the life span. Migration and ethnicity may modify the lifetime trajectory of socioeconomic status (SES) and lead to heterogeneity in cognitive aging in later life.
We examined the effects of both lifetime socioeconomic trajectory and cumulative disadvantage from childhood through adulthood on late life cognitive performance in a 9-year cohort of 1,789 Mexican Americans aged 60-100 years in 1998-1999.
Compared with those with low SES sustained over the life course, we found that those with more advantaged lifetime SES trajectories experienced fewer declines on a test of global cognitive function and a short-term verbal memory test. These associations are larger in first- and second-generation immigrant families.
Heterogeneity of cognitive aging among diverse race/ethnic groups may be influenced by intergenerational changes in SES, cultural norms, and behaviors and changes in health related to changes in the social and physical environment.
人生早期的环境会影响整个生命周期的健康。移民和种族可能会改变社会经济地位（SES）的终身轨迹，并导致晚年认知衰老的异质性。
我们在 1998-1999 年对 1789 名年龄在 60-100 岁的墨西哥裔美国人进行了一项为期 9 年的队列研究，调查了从童年到成年的整个生命周期 SES 轨迹和累积劣势对晚年认知表现的影响。
与那些一生中 SES 一直较低的人相比，我们发现那些 SES 轨迹更为有利的人在全球认知功能测试和短期语言记忆测试中的衰退程度较少。这些关联在第一代和第二代移民家庭中更大。
不同种族/族裔群体认知衰老的异质性可能受到 SES、文化规范和行为的代际变化以及与社会和物理环境变化相关的健康变化的影响。
