Yao Y Z
Beijing Thorax Tumor Institute.
Zhonghua Jie He He Hu Xi Za Zhi. 1990 Jun;13(3):133-5, 189.
CEA (Carcinoembryonic Antigen) was examined histochemically with PAP method in 150 lung cancer cases. Positive stainings were observed in 89% of adenosquamous cancers, 79.2% of adenocarcinomas (ACs), 63.3% of squamous cell cancers (SCCs), 55.6% of large cell cancers (LCCs) and 51.6% of small cell lung cancers (SCLCs). In ACs and SCCs, the higher cancer cells differentiated, the higher positive rates were observed. The intensities from high to low as followings: ACs and adenosquamous cancers; SCLCs and SCCs; and LCCs. Cytoplasmic staining was predominantly found in ACs (76%) and adenosquamous cancers (68.8), membranous in SCCs (63%) and LCCs (60%), and intercellular in SCLCs (68.8%). The results suggests that CEA is significantly related to differential degree of lung cancers. The different staining patterns and positive rates and intensities of CEA may be helpful for the pathological classification of lung cancers. Finally, the author indicates that CEA immunohistochemical examination will be a useful measure for exactly selecting lung cancer cases suitable for radioimmunodetection and antibody-mediated therapy.
采用PAP法对150例肺癌患者的癌胚抗原（CEA）进行了组织化学检测。在腺鳞癌中89%观察到阳性染色，腺癌（AC）中为79.2%，鳞状细胞癌（SCC）中为63.3%，大细胞癌（LCC）中为55.6%，小细胞肺癌（SCLC）中为51.6%。在AC和SCC中，癌细胞分化程度越高，阳性率越高。强度从高到低依次为：AC和腺鳞癌；SCLC和SCC；以及LCC。细胞质染色主要见于AC（76%）和腺鳞癌（68.8%），膜染色见于SCC（63%）和LCC（60%），细胞间染色见于SCLC（68.8%）。结果表明CEA与肺癌的分化程度显著相关。CEA不同的染色模式、阳性率和强度可能有助于肺癌的病理分类。最后，作者指出CEA免疫组化检测将是准确选择适合放射免疫检测和抗体介导治疗的肺癌病例的有用措施。
