口腔白斑病和口腔癌患者的唾液和血清白细胞介素 1β、白细胞介素 6 和肿瘤坏死因子α。
Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer.
机构信息
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
出版信息
Med Oral Patol Oral Cir Bucal. 2012 Jan 1;17(1):e10-5. doi: 10.4317/medoral.17323.
OBJECTIVES
The aim of study was to compare salivary and serum concentrations of interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in patients with oral leukoplakia, oral cancer and healthy controls.
STUDY DESIGN
Eighty eight patients (28 with oral cancer, 29 leukoplakia, and 31 healthy controls) were included in this study. Cytokine concentrations were measured by commercial enzyme linked immunoassay.
RESULTS
Salivary IL-1β and IL-6 were significantly higher in oral cancer patients than in patients with leukoplakia and control group (p<0.05). No differences in concentrations of salivary TNF-α between either of the groups were observed. Serum concentrations of IL-1β were below level of detection in all but two participants. No significant differences between the groups were observed in serum concentrations of IL-6. Serum TNF-α was significantly higher in control subjects than in oral cancer patients.
CONCLUSIONS
Patients with oral cancer have elevated levels of inflammatory cytokines in their saliva. Whether this elevation can be used for monitoring the malignant transformation of oral leukoplakia remains to be answered by further follow up studies.
目的
本研究旨在比较口腔白斑、口腔癌患者与健康对照者唾液和血清中白细胞介素 1β（IL-1β）、白细胞介素 6（IL-6）和肿瘤坏死因子α（TNF-α）的浓度。
设计
本研究纳入了 88 名患者（28 名口腔癌患者、29 名口腔白斑患者和 31 名健康对照者）。采用商业酶联免疫吸附试验测定细胞因子浓度。
结果
口腔癌患者的唾液 IL-1β 和 IL-6 浓度明显高于口腔白斑患者和对照组（p<0.05）。三组间唾液 TNF-α 浓度无差异。血清中 IL-1β 浓度除了两名参与者外，其余均低于检测水平。三组间血清 IL-6 浓度无显著差异。对照组的血清 TNF-α 浓度明显高于口腔癌患者。
结论
口腔癌患者的唾液中炎症细胞因子水平升高。这种升高是否可用于监测口腔白斑的恶性转化，有待进一步的随访研究来回答。
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