男性精神分裂症患者血清中单羟苯乙酸和性腺激素浓度。

Concentrations of homovanillic Acid and gonadal hormones in the serum of male schizophrenic patients.

机构信息

S.L. Gong, PhD, Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Wellcome building, Science site, University of Wales, Bangor, Gwynedd LL57 2UW, United Kingdom.

出版信息

Indian J Psychiatry. 1993 Jul;35(3):181-3.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2978493/

Abstract

The concentrations of serum homovanillic acid (HVA), luteinizing liormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) were examined in 20 male schizophrenic patients not taking neuroleptic drugs, 44 treated with neuroleptic drugs, and 15 male healthy control subjects. Kurskal-Wallis analysis of variance showed no significant difference among the three groups in serum HVA, FSH, LH or testosterone although high concentrations were found in tlte patients not taking neuroleptic drugs. There was a significant positive correlation between serum HVA and FSH in the patients not taking neuroleptics. The present results suggest that the change of gonadal hormones may be related to the pathogenesis of schizophrenia.

摘要

我们检测了 20 名未服用抗精神病药物的男性精神分裂症患者、44 名服用抗精神病药物的男性精神分裂症患者和 15 名男性健康对照者的血清高香草酸（HVA）、黄体生成素（LH）、卵泡刺激素（FSH）和睾酮（T）浓度。尽管未服用抗精神病药物的患者的血清 HVA、FSH、LH 或睾酮浓度较高，但克朗巴赫-哈里斯方差分析显示三组之间无显著差异。未服用抗精神病药物的患者的血清 HVA 与 FSH 之间呈显著正相关。目前的结果表明，性腺激素的变化可能与精神分裂症的发病机制有关。

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