Lapin I P, Mirzaev S, Prakh'e I B, Ryzhov I V
Fiziol Zh SSSR Im I M Sechenova. 1990 Jul;76(7):849-54.
Behaviour of SHR, C57B1/6 male mice and common albino male rats treated intracerebroventricularly or intraperitoneally with kynurenine, quinolinic, kynurenic, picolinic, xanthurenic, anthranilic acids and nicotinamide, was studied in the dark/light chamber. Quinolinic acid and its precursor kynurenine diminished dark preference, increased the number of transitions between dark and light compartments, diminished locomotion in light compartment. Biogenic amine phenylethylamine with its typical anxiogenic activity, exerted a similar action. Diazepam acted in the opposite way. Noncompetitive antagonist of the NMDA receptors, kynurenic acid, prevented the effect of quinolinic acid. The hole reflex appears to be a useful simple object to study neuroactive endogenous compounds on.
在明暗箱中研究了经脑室或腹腔注射犬尿氨酸、喹啉酸、犬尿酸、吡啶甲酸、黄尿酸、邻氨基苯甲酸和烟酰胺的自发性高血压大鼠（SHR）、C57B1/6雄性小鼠和普通白化雄性大鼠的行为。喹啉酸及其前体犬尿氨酸减少了对黑暗的偏好，增加了明暗隔室之间的转换次数，减少了在明隔室中的活动。具有典型致焦虑活性的生物胺苯乙胺也有类似作用。地西泮的作用则相反。NMDA受体的非竞争性拮抗剂犬尿酸可阻止喹啉酸的作用。洞反射似乎是研究神经活性内源性化合物的一个有用的简单对象。
