Chemistry Division, Indian Institute of Chemical Biology (CSIR), Kolkata, India.
Org Biomol Chem. 2011 Aug 21;9(16):5856-62. doi: 10.1039/c1ob05255a. Epub 2011 Jul 8.
We report a general and facile method that provides rapid entry into 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues in one-pot under palladium-copper catalysis. The methodology utilises simple and easily available substrates of broad range. The applicability of this reaction for the synthesis of optically active products has been demonstrated. A plausible reaction mechanism has also been proposed.
我们报道了一种通用且简便的方法，该方法在钯-铜催化下一锅法快速合成 3-芳基取代的 4,5,6,7-四氢[1,2,3]三唑并[1,5-a]吡嗪及其稠合类似物。该方法利用了简单易得的底物，适用范围广泛。该反应在光学活性产物的合成中具有适用性。还提出了一个合理的反应机制。
