Lesniewska B, Nowak M, Miskowiak B, Nussdorfer G G, Malendowicz L K
Department of Histology and Embryology, Poznan Academy of Medicine, Poland.
Neuropeptides. 1990 May;16(1):9-13. doi: 10.1016/0143-4179(90)90023-r.
Adult female rats, intact or dexamethasone suppressed, were i.p. injected twice a day for 4 consecutive days with 0.5 ug neuropeptide-Y (NPY). In intact rats, NPY lowered serum ACTH and aldosterone levels, and had no effects either on serum and adrenal corticosterone or the morphology of the adrenal cortex. In dexamethasone-treated rats, NPY again decreased serum aldosterone concentration. Moreover, it caused a small but significant drop both in the volume of zona fasciculata cells and the adrenal content of corticosterone. These findings seem to suggest an inhibitory effect of NPY on the function of rat zona glomerulosa and perhaps zona fasciculata.
成年雌性大鼠，分为完整组或地塞米松抑制组，连续4天每天腹腔注射两次0.5微克神经肽Y（NPY）。在完整大鼠中，NPY降低了血清促肾上腺皮质激素（ACTH）和醛固酮水平，对血清和肾上腺皮质酮以及肾上腺皮质形态均无影响。在地塞米松处理的大鼠中，NPY再次降低了血清醛固酮浓度。此外，它使束状带细胞体积和肾上腺皮质酮含量均出现小幅但显著的下降。这些发现似乎表明NPY对大鼠球状带功能可能还有束状带功能具有抑制作用。
