5-HTTLPR 和 BDNF Val66Met 多态性调节应激对反刍思维的影响。
5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.
机构信息
Department of Psychology, The University of Texas at Austin, Austin, TX 78712-0187, USA.
出版信息
Genes Brain Behav. 2011 Oct;10(7):740-6. doi: 10.1111/j.1601-183X.2011.00715.x. Epub 2011 Aug 1.
Abstract
This study examined whether polymorphisms in the serotonin transporter (SLC6A4, 5-HTTLPR) and brain-derived neurotropic factor (BDNF Val66Met, rs6265) genes moderate the relationship between life stress and rumination. Participants were a large homogenous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 273). Results indicate that individuals with two short (S) alleles of the 5-HTTLPR polymorphism or two Met alleles of the BDNF Val66Met polymorphism ruminate more under conditions of life stress, compared to the other genotypes. Moreover, the accumulation of risk alleles (i.e. S and Met alleles) across genes is associated with significantly greater rumination in the context of life stress. These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. These findings support the notion that variation in these genes is associated with biological sensitivity to the negative effects of stress.
摘要
这项研究考察了 5-羟色胺转运体（SLC6A4，5-HTTLPR）和脑源性神经营养因子（BDNF Val66Met，rs6265）基因中的多态性是否调节生活压力与反刍思维之间的关系。参与者是一组来自健康、未用药、无抑郁病史且当前抑郁症状较少的同质人群（N=273）。结果表明，与其他基因型相比，5-HTTLPR 多态性的两个短（S）等位基因或 BDNF Val66Met 多态性的两个 Met 等位基因的个体在生活压力下更易反刍。此外，跨基因的风险等位基因（即 S 和 Met 等位基因）的积累与生活压力下明显更大的反刍相关。这些结果表明，5-HTTLPR 和 BDNF Val66Met 均调节生活压力与反刍思维之间的关系。这些发现支持这样一种观点，即这些基因的变异与对压力的负面影响的生物敏感性有关。
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