Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Fitoterapia. 2011 Oct;82(7):1035-8. doi: 10.1016/j.fitote.2011.06.010. Epub 2011 Jul 2.
Two new sesquiterpenoids, identified as (rel 1S, 3R, 4R, 7R)-3-[5-hydroxy-4-methylpent-3-enyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (1) and (rel 1S, 3R, 4R, 7R)-3-[3, 4-dihydroxy-4-methylpentyl]-1, 3, 7-trimethyl-2-oxabicyclo [2, 2, 1] heptane (2), were isolated from cultures of Trichoderma atroviride (strain no. S361), an endophytic fungal strain residing in the bark of Cephalotaxus fortunei. The structures of compounds 1 and 2 were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Both compounds 1 and 2 were potent inhibitors on NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ values of 15.3 and 9.1μM, respectively.
从 Cephalotaxus fortunei 树皮内生真菌 Trichoderma atroviride (菌株编号 S361) 的培养物中分离得到两种新的倍半萜类化合物，分别鉴定为 (rel 1S, 3R, 4R, 7R)-3-[5-羟基-4-甲基戊-3-烯基]-1,3,7-三甲基-2-氧杂双环[2,2,1]庚烷（1）和 (rel 1S, 3R, 4R, 7R)-3-[3,4-二羟基-4-甲基戊基]-1,3,7-三甲基-2-氧杂双环[2,2,1]庚烷（2）。化合物 1 和 2 的结构通过基于 NMR、IR 和 MS 数据的详细光谱分析阐明。化合物 1 和 2 均对 LPS 刺激的 RAW264.7 细胞中 NO 的产生具有强烈的抑制作用，IC₅₀ 值分别为 15.3 和 9.1μM。
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