Zhang Jian-Long, Tang Wen-Li, Huang Qing-Rong, Li You-Zhi, Wei Mao-Lian, Jiang Lin-Lin, Liu Chong, Yu Xin, Zhu Hong-Wei, Chen Guo-Zhong, Zhang Xing-Xiao
School of Life Sciences, Ludong University, Yantai, China.
Shandong Provincial Key Laboratory of Quality Safty Monitoring and Risk Assessment for Animal Products, Jinan, China.
Front Microbiol. 2021 Jul 23;12:723828. doi: 10.3389/fmicb.2021.723828. eCollection 2021.
Fungi play an irreplaceable role in drug discovery in the course of human history, as they possess unique abilities to synthesize diverse specialized metabolites with significant medicinal potential. are well-studied filamentous fungi generally observed in nature, which are widely marketed as biocontrol agents. The secondary metabolites produced by have gained extensive attention since they possess attractive chemical structures with remarkable biological activities. A large number of metabolites have been isolated from species in recent years. A previous review by Reino et al. summarized 186 compounds isolated from as well as their biological activities up to 2008. To update the relevant list of reviews of secondary metabolites produced from sp., we provide a comprehensive overview in regard to the newly described metabolites of from the beginning of 2009 to the end of 2020, with emphasis on their chemistry and various bioactivities. A total of 203 compounds with considerable bioactivities are included in this review, which is worth expecting for the discovery of new drug leads and agrochemicals in the foreseeable future. Moreover, new strategies for discovering secondary metabolites of in recent years are also discussed herein.
在人类历史进程中，真菌在药物发现方面发挥着不可替代的作用，因为它们具有合成多种具有重要药用潜力的特殊代谢产物的独特能力。 是自然界中普遍观察到的经过充分研究的丝状真菌，作为生物防治剂被广泛销售。 产生的次生代谢产物因其具有吸引人的化学结构和显著的生物活性而受到广泛关注。近年来，已从 物种中分离出大量代谢产物。Reino等人之前的一篇综述总结了截至2008年从 中分离出的186种化合物及其生物活性。为了更新有关 产生的次生代谢产物的综述相关列表，我们全面概述了2009年初至2020年底 新描述的代谢产物，重点关注其化学性质和各种生物活性。本综述共纳入了203种具有相当生物活性的化合物，有望在可预见的未来发现新的药物先导物和农用化学品。此外，本文还讨论了近年来发现 次生代谢产物的新策略。
