School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Planta Med. 2012 Jan;78(2):166-71. doi: 10.1055/s-0031-1280294. Epub 2011 Oct 14.
A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC₅₀ values of 7.39 ± 0.36, 6.35 ± 0.26, and 5.39 ± 0.18 µM, respectively.
从旋覆花（Inula racemosa Hook. f.）的根部分离得到了一种新型倍半萜（1），三种新的倍半萜（2-4）和 10 种已知的倍半萜。通过广泛的光谱和计算方法阐明了新倍半萜的结构和绝对构型。所有化合物均评估了其对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮产生的抑制作用，结果表明化合物 9、12 和 13 适度抑制了一氧化氮的产生，其 IC₅₀ 值分别为 7.39 ± 0.36、6.35 ± 0.26 和 5.39 ± 0.18 µM。
