Department of Surgery, Division of Transplantation, Medical University Graz, Austria.
Ageing Res Rev. 2012 Jan;11(1):181-7. doi: 10.1016/j.arr.2011.06.003. Epub 2011 Jul 1.
Many transplant studies in elderly patients focus on survival and mortality rates. It was the aim of this review to evaluate publications dealing with individual patient performance and independence.
The literature search included all articles retrievable for the hit "transplantation in elderly recipients" between 1960 and 2010. For quality search the inclusion criteria were as follows: older than 60 years and transplanted kidney, liver, heart, lung or pancreas from a deceased or living donor. We focussed on parameters concerning quality of life, frailty, nutritional status/weight loss, drugs/interactions/polypharmacy, gait/osteoporosis/fracture, delirium/dementia and geriatric assessment to address physical and psychosocial functionality of elderly recipients.
The initial hit list contained 1427 citations from electronic databases. 249 abstracts thereof were selected for full review. A total of 60 articles met final inclusion criteria. Finally, only five studies met the qualitative inclusion criteria as listed above.
The number of elderly patients placed on waiting lists has increased dramatically and will further grow. Interdisciplinary collaboration and distinct patient selection is recommended in most of the studies. However, data concerning quality of life and related parameters in elderly transplant recipients are rare.
许多针对老年患者的移植研究都集中在生存率和死亡率上。本研究旨在评估涉及个体患者表现和独立性的出版物。
文献检索包括 1960 年至 2010 年期间所有关于“老年受者移植”的文章。为了进行质量搜索，纳入标准如下：年龄大于 60 岁，接受过来自已故或活体供者的肾、肝、心脏、肺或胰腺移植。我们重点关注与生活质量、虚弱、营养状况/体重减轻、药物/相互作用/多药治疗、步态/骨质疏松/骨折、谵妄/痴呆和老年评估相关的参数，以评估老年受者的身体和心理社会功能。
最初的电子数据库命中列表包含 1427 条引文。从中选择了 249 篇摘要进行全面审查。共有 60 篇文章最终符合纳入标准。最后，只有五项研究符合上述定性纳入标准。
等待名单上的老年患者数量急剧增加，而且还会进一步增加。大多数研究都建议进行跨学科合作和明确的患者选择。然而，关于老年移植受者的生活质量和相关参数的数据却很少。
