Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Nutr Res. 2011 Jun;31(6):421-8. doi: 10.1016/j.nutres.2011.05.004. Epub 2011 Jun 17.
Water-soluble black Chinese (Pu-Erh) tea extract (BTE), which contains high gallic acid content, has been demonstrated to elicit antiobese effects in animals. Because gallic acid is related with the reduction of visceral fat and cholesterol contents and improvement of obesity in animals, we investigated the effects of BTE intake on 36 preobese Japanese adults (body mass index [BMI], >25- <30 kg/m(2)) in a 12-week double-blind, randomized, placebo-controlled group comparison study using powdered barley tea with or without (placebo) BTE. A follow-up 4-week period after BTE intake termination was monitored to observe the withdrawal effect. All subjects ingested barley tea with or without BTE (333 mg) before each of the 3 daily meals. In the BTE-treated group, the mean pretreament values of body weight and BMI significantly decreased after intake and after BTE withdrawal. However, the corresponding values scored significant differences only from 8 weeks after intake (vs the placebo-treated group). The mean values of the waist circumference indicated a similar tendency. Furthermore, coronal navel section (same anatomical position) images of computed tomography of all BTE- and non-BTE-treated subjects revealed that the visceral fat areas (cm(2)) were significantly (P < .05) less in the former 12 weeks after BTE ingestion. Measured biochemical parameters did not indicate significant differences, and BTE-treated subjects did not complain of any adverse effects (abdominal distension, etc). Ingestion of BTE exhibited significant effects in reducing the mean waist circumference, BMI, and visceral fat values and might be useful for weight control and prevention of obesity development (or metabolic syndrome) in humans.
水溶性黑茶(Pu-Erh)提取物(BTE)含有高浓度的没食子酸,已被证明在动物中具有抗肥胖作用。因为没食子酸与减少内脏脂肪和胆固醇含量以及改善动物肥胖有关,我们在一项为期 12 周的双盲、随机、安慰剂对照的组间比较研究中,调查了 BTE 摄入对 36 名超重的日本成年人(体重指数[BMI],>25- <30 kg/m(2)) 的影响。在 BTE 摄入结束后进行了为期 4 周的随访,以观察停药效果。所有受试者在每日三餐前分别摄入含或不含 BTE(333mg)的大麦茶。在 BTE 治疗组中,治疗前的体重和 BMI 值在摄入后和 BTE 停药后显著下降。然而,只有在摄入 8 周后(与安慰剂治疗组相比),相应的值才显示出显著差异。腰围的平均值也呈现出类似的趋势。此外,所有接受 BTE 和非 BTE 治疗的受试者的计算机断层扫描冠状脐部切片(相同解剖位置)图像显示,BTE 摄入后 12 周内,内脏脂肪面积(cm(2))显著减少(P<.05)。测量的生化参数没有显示出显著差异,而且 BTE 治疗组的受试者没有抱怨任何不良反应(腹胀等)。BTE 的摄入在减少平均腰围、BMI 和内脏脂肪值方面表现出显著效果,可能对控制体重和预防肥胖发展(或代谢综合征)有用。