Morimoto-Kobayashi Yumie, Ohara Kazuaki, Ashigai Hiroshi, Kanaya Tomoka, Koizumi Kumiko, Manabe Fumitoshi, Kaneko Yuji, Taniguchi Yoshimasa, Katayama Mikio, Kowatari Yasuyuki, Kondo Sumio
Research Laboratories for Health Science and Food Technologies, Kirin Company, Ltd, 1-13-5, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Central Laboratories for Key Technologies, Kirin Company, Ltd, 1-13-5, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Nutr J. 2016 Mar 9;15:25. doi: 10.1186/s12937-016-0144-2.
Hops are the main components of beer that provide flavor and bitterness. Iso-α-acids, the bitter components of beer, have been reported to reduce body fat in humans, but the bitterness induced by effective doses of iso-α-acids precludes their acceptance as a nutrient. The matured hop bitter acids (MHBA) of oxidized hops appear to have a more pleasant bitterness compared to the sharper bitterness of iso-α-acids. While there has been little information concerning the identity of the MHBA compounds and their physiological effects, MHBA was recently found to be primarily composed of oxides derived from α-acids, and structurally similar to iso-α-acids. Here, we investigated the effects of matured hop extract (MHE) containing MHBA on reducing abdominal body fat in healthy subjects with a body mass index (BMI) of 25 to below 30 kg/m(2), classified as "obese level 1" in Japan or as "overweight" by the WHO.
A randomized, double-blind, placebo-controlled parallel group study.
Two hundred subjects (male and female aged 20 to below 65 years with a BMI of 25 or more and less than 30 kg/m(2)) were randomly assigned to two groups. During a 12-week ingestion period, the subjects in each group ingested daily 350 mL of test-beverage, either containing MHE (with 35 mg MHBA), i.e. the namely active beverage, or a placebo beverage without MHE. The primary endpoint was reduction of the abdominal fat area as determined by CT scanning after continual ingestion of MHE for 12 weeks.
Compared to the placebo group, a significant reduction was observed in the visceral fat area after 8 and 12 w, and in the total fat area after 12 w in the active group. There was also a concomitant decrease in body fat ratio in the active group compared to the placebo group. No adverse events related to the test beverages or clinically relevant abnormal changes in the circulatory, blood and urine parameters were observed in either group.
The present study suggests that continual ingestion of MHE safely reduces body fat, particularly the abdominal visceral fat of healthy overweight subjects.
UMIN-CTR UMIN000014185.
啤酒花是啤酒的主要成分，赋予啤酒风味和苦味。据报道，啤酒中的苦味成分异α-酸可减少人体脂肪，但有效剂量的异α-酸所带来的苦味使其难以被作为一种营养物质接受。与异α-酸尖锐的苦味相比，氧化啤酒花中的成熟啤酒花苦味酸（MHBA）似乎具有更宜人的苦味。虽然关于MHBA化合物的身份及其生理作用的信息很少，但最近发现MHBA主要由α-酸衍生的氧化物组成，并且在结构上与异α-酸相似。在此，我们研究了含有MHBA的成熟啤酒花提取物（MHE）对体重指数（BMI）在25至30kg/m²以下的健康受试者腹部脂肪减少的影响，在日本这些受试者被归类为“肥胖1级”，或被世界卫生组织归类为“超重”。
一项随机、双盲、安慰剂对照平行组研究。
200名受试者（年龄在20至65岁以下，BMI为25或更高且低于30kg/m²的男性和女性）被随机分为两组。在为期12周的摄入期内，每组受试者每天饮用350mL试验饮料，一种含有MHE（含35mg MHBA），即活性饮料，另一种是不含MHE的安慰剂饮料。主要终点是在连续摄入MHE 12周后通过CT扫描确定的腹部脂肪面积的减少。
与安慰剂组相比，活性组在8周和12周后内脏脂肪面积显著减少，在12周后总脂肪面积显著减少。与安慰剂组相比，活性组的体脂率也随之降低。两组均未观察到与试验饮料相关的不良事件或循环、血液和尿液参数的临床相关异常变化。
本研究表明，持续摄入MHE可安全地减少体脂，特别是健康超重受试者的腹部内脏脂肪。
UMIN-CTR UMIN000014185。
