Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA 98195, USA.
Virology. 2011 Sep 1;417(2):312-9. doi: 10.1016/j.virol.2011.06.014. Epub 2011 Jul 13.
The relationship between virulence and overall within-host fitness of the fish rhabdovirus Infectious hematopoietic necrosis virus (IHNV) was empirically investigated in vivo for two virus isolates belonging to different IHNV genogroups that exhibit opposing host-specific virulence. U group isolates are more virulent in sockeye salmon and M group isolates are more virulent in rainbow trout. In both single and mixed infections in the two fish hosts, the more virulent IHNV type exhibited higher prevalence and higher viral load than the less virulent type. Thus, a positive correlation was observed between higher in vivo fitness and higher host-specific virulence in sockeye salmon and rainbow trout. Comparisons of mean viral loads in single and mixed infections revealed no evidence for limitation due to competition effects between U and M viruses in either rainbow trout or sockeye salmon co-infections.
我们通过体内实验实证研究了两种属于不同基因群的鱼弹状病毒——传染性造血器官坏死病毒（IHNV）的毒力与其在宿主内的整体适应力之间的关系。U 群分离株在红大麻哈鱼中更具毒力，而 M 群分离株在虹鳟鱼中更具毒力。在两种宿主的单一和混合感染中，毒力更强的 IHNV 类型比毒力较弱的类型具有更高的流行率和更高的病毒载量。因此，在红大麻哈鱼和虹鳟鱼中，更高的体内适应力与更高的宿主特异性毒力之间存在正相关关系。在单一和混合感染中比较平均病毒载量，没有证据表明 U 和 M 病毒在虹鳟鱼或红大麻哈鱼的共感染中因竞争效应而受到限制。
