含有主要病毒糖蛋白的免疫刺激复合物（ISCOMs）对仓鼠抵抗致死性1型马疱疹病毒（1型亚型）感染的保护作用。
Protection against lethal equine herpes virus type 1 (subtype 1) infection in hamsters by immune stimulating complexes (ISCOMs) containing the major viral glycoproteins.
作者信息
Cook R F, O'Neill T, Strachan E, Sundquist B, Mumford J A
机构信息
Department of Infectious Diseases, Animal Health Trust, Newmarket, Suffolk, UK.
出版信息
Vaccine. 1990 Oct;8(5):491-6. doi: 10.1016/0264-410x(90)90252-h.
An experimental ISCOM vaccine has been prepared from gradient purified equine herpes virus type 1 (EHV-1). Radiolabelling studies demonstrated that this vaccine contained all the major viral glycoproteins in relative amounts similar to those found in non-detergent disrupted viral preparations. This EHV-1 ISCOM vaccine generated fully protective responses in hamsters challenged with an otherwise lethal dose of the hamster-adapted EHV-1 strain RACH.
一种实验性免疫刺激复合物（ISCOM）疫苗是由梯度纯化的马疱疹病毒1型（EHV-1）制备而成。放射性标记研究表明，该疫苗含有所有主要病毒糖蛋白，其相对含量与在非去污剂破坏的病毒制剂中发现的相似。这种EHV-1 ISCOM疫苗在用致死剂量的仓鼠适应EHV-1毒株RACH攻击的仓鼠中产生了完全的保护反应。
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