Linden A, Art T, Amory H, Desmecht D, Lekeux P
Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Belgium.
Zentralbl Veterinarmed A. 1990 Sep;37(8):601-4.
Seven sport horses were investigated to compare physiological and pharmacological stresses on the plasma glucocorticosteroid levels. Venous blood was sampled and analysed for cortisol concentrations before and after each type of stress. The physiological stress was induced by the completion of a cross-country and the pharmacological one, by an intravenous ACTH administration (200 micrograms) in the same horses, one week after the course. Both exercise and ACTH injection induced a highly significant cortisol increase of 79 +/- 0.10% and 160 +/- 0.18%, respectively. The relative plasma cortisol increases due to exercise on the one hand, and due to ACTH administration on the other hand, were correlated with a coefficient of 0.82. It was concluded that the plasma cortisol increase induced by a standardised pharmacological stress could be used in order to predict the exercise-induced stress response.
研究了7匹运动马，以比较生理和药理应激对血浆糖皮质激素水平的影响。在每种应激前后采集静脉血样并分析皮质醇浓度。生理应激通过完成越野赛诱导，药理应激则在课程结束一周后，对同一批马静脉注射促肾上腺皮质激素（200微克）诱导。运动和促肾上腺皮质激素注射均分别引起皮质醇高度显著增加，增幅分别为79±0.10%和160±0.18%。一方面，运动导致的血浆皮质醇相对增加与另一方面促肾上腺皮质激素给药导致的增加之间的相关系数为0.82。得出的结论是，标准化药理应激诱导的血浆皮质醇增加可用于预测运动诱导的应激反应。
