Department of Animal Medicine and Surgery, Veterinary Faculty, University of Murcia, Murcia 30100, Spain.
Res Vet Sci. 2012 Aug;93(1):103-7. doi: 10.1016/j.rvsc.2011.05.013.
No detailed comparative data are available on the hormonal parameters of horses suffering from a number of diseases. The aim of our study was to measure concentrations of cortisol, adrenocorticotropic hormone (ACTH), serotonin, adrenaline and noradrenaline in horses with various diseases and following surgery, to assess the response of the HPA axis and adrenal medulla. Blood samples were obtained from six groups of horses comprising a total of 119 animals as follows: laminitis, acute abdominal syndrome (AAS), castration surgery, acute diseases, chronic diseases and healthy controls. Serum hormonal concentrations were determined for each group for comparison. Statistically significant differences between all groups and controls were found for cortisol, ACTH (except for castration), serotonin and adrenaline concentrations but only in horses with laminitis and AAS for noradrenaline. No statistically significant differences were found between males and females. The largest changes in the pituitary-adrenal axis activity occurred mainly in acute diseases, laminitis and in the AAS group.
目前尚无关于患有多种疾病的马匹的激素参数的详细对比数据。我们的研究目的是测量患有各种疾病和手术后的马匹的皮质醇、促肾上腺皮质激素（ACTH）、血清素、肾上腺素和去甲肾上腺素的浓度，以评估 HPA 轴和肾上腺髓质的反应。从以下六个组别的马匹中采集了血液样本，总共有 119 匹马：蹄叶炎、急性腹部综合征（AAS）、阉割手术、急性疾病、慢性疾病和健康对照组。为每组确定了血清激素浓度以进行比较。皮质醇、ACTH（除阉割外）、血清素和肾上腺素浓度在所有组与对照组之间存在统计学显著差异，但仅在蹄叶炎和 AAS 组的马匹中存在去甲肾上腺素差异。在雄性和雌性之间未发现统计学显著差异。主要在急性疾病、蹄叶炎和 AAS 组中观察到垂体-肾上腺轴活性的最大变化。
