Påhlman S, Hammerling U
Department of Pathology, University of Uppsala, Sweden.
Am Rev Respir Dis. 1990 Dec;142(6 Pt 2):S54-6. doi: 10.1164/ajrccm/142.6_Pt_2.S54.
The proto-oncogene c-src codes for two tyrosine kinases, pp60c-src and pp60c-srcN. The latter protein appears to be exclusively expressed in neurons and neuronally differentiated tumors. In cell lines derived from neuroblastoma and small-cell lung carcinoma, src expression correlates positively with neuroendocrine differentiation. However, pp60c-srcN is expressed only in highly differentiated neuroblastomas. Although c-src expression in neuroendocrine tumors probably reflects and is the result of the differentiation stage at which the tumors have been arrested, high c-src expression and kinase activities in non-neuroectodermal tumors, e.g., colon carcinoma, breast carcinoma, might instead be a part of the malignant phenotype and contribute to the development of these tumors.
原癌基因c-src编码两种酪氨酸激酶，即pp60c-src和pp60c-srcN。后一种蛋白似乎仅在神经元及神经分化肿瘤中表达。在源自神经母细胞瘤和小细胞肺癌的细胞系中，src表达与神经内分泌分化呈正相关。然而，pp60c-srcN仅在高分化神经母细胞瘤中表达。尽管神经内分泌肿瘤中的c-src表达可能反映了肿瘤所处的分化阶段且是该阶段的结果，但在非神经外胚层肿瘤（如结肠癌、乳腺癌）中，高c-src表达和激酶活性可能反而构成恶性表型的一部分，并促进这些肿瘤的发展。
