Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Campus Avançado Asa Norte, SGAN 916 Avenida W5, CEP: 70790-160, Brasilia, DF, Brazil.
FASEB J. 2011 Oct;25(10):3290-305. doi: 10.1096/fj.11-184291. Epub 2011 Jul 11.
Storage proteins perform essential roles in plant survival, acting as molecular reserves important for plant growth and maintenance, as well as being involved in defense mechanisms by virtue of their properties as insecticidal and antimicrobial proteins. These proteins accumulate in storage vacuoles inside plant cells, and, in response to determined signals, they may be used by the different plant tissues in response to pathogen attack. To shed some light on these remarkable proteins with dual functions, storage proteins found in germinative tissues, such as seeds and kernels, and in vegetative tissues, such as tubercles and leaves, are extensively discussed here, along with the related mechanisms of protein expression. Among these proteins, we focus on 2S albumins, Kunitz proteinase inhibitors, plant lectins, glycine-rich proteins, vicilins, patatins, tarins, and ocatins. Finally, the potential use of these molecules in development of drugs to combat human and plant pathogens, contributing to the development of new biotechnology-based medications and products for agribusiness, is also presented.
贮藏蛋白在植物生存中发挥着重要作用，作为分子储备物质，对植物的生长和维持至关重要，同时还具有杀虫和抗菌蛋白的特性，参与防御机制。这些蛋白质在植物细胞的储存液泡中积累，并且可以根据特定的信号被不同的植物组织利用，以应对病原体的攻击。为了深入了解这些具有双重功能的非凡蛋白质，本文广泛讨论了存在于生殖组织（如种子和谷物）和营养组织（如块茎和叶片）中的贮藏蛋白，以及相关的蛋白质表达机制。在这些蛋白质中，我们重点介绍 2S 清蛋白、Kunitz 蛋白酶抑制剂、植物凝集素、富含甘氨酸的蛋白质、vicilins、patatins、tarins 和 octins。最后，还介绍了这些分子在开发针对人类和植物病原体的药物方面的潜在应用，这有助于开发基于新生物技术的农业综合企业药物和产品。
