Song Minghui, Zhou Yunbing, Li Gang, Barashkova Anna S, Rogozhin Eugene A, Chang Wenqiang
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.
Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, China.
Cell Surf. 2025 May 15;13:100145. doi: 10.1016/j.tcsw.2025.100145. eCollection 2025 Jun.
As dynamic interfaces governing molecular recognition and signal transduction, interactions between plants and microbes fundamentally shape ecosystem dynamics and evolutionary trajectories. This review summarizes peptides involved in plant-microbe interactions, emphasizing their diversity, biological functions mediated at the cell surface, pharmacological applications, and recent methodological advances in their discovery. Plant-derived peptides, including cysteine-rich peptides (NCRs, RALFs, DEFs, nsLTPs) and post-translationally modified peptides (CLEs, CEPs, GLV/RGF, PSKs), regulate symbiotic relationships and plant defenses. Endophyte-derived peptides, notably lipopeptides (surfactins, fengycins, iturins), exhibit pathogen inhibition and plant growth promotion. Additionally, plant polypeptides such as lipid transfer proteins, hevein-like peptides, thionins, defensins, and snakins significantly enhance plant immunity through direct antimicrobial action and systemic resistance. Technological advancements in isolation techniques, multi-omics approaches, bioinformatics, and artificial intelligence have accelerated peptide discovery. However, challenges remain regarding functional characterization, peptide stability, production costs, and ecological impacts. Addressing these through interdisciplinary research and collaboration will promote practical applications of peptides in agriculture and medicine.
作为控制分子识别和信号转导的动态界面，植物与微生物之间的相互作用从根本上塑造了生态系统动态和进化轨迹。本综述总结了参与植物-微生物相互作用的肽，强调了它们的多样性、在细胞表面介导的生物学功能、药理学应用以及发现它们的最新方法进展。植物来源的肽，包括富含半胱氨酸的肽（NCRs、RALFs、DEFs、nsLTPs）和翻译后修饰的肽（CLEs、CEPs、GLV/RGF、PSKs），调节共生关系和植物防御。内生菌来源的肽，特别是脂肽（表面活性素、丰原素、伊枯草菌素），具有抑制病原体和促进植物生长的作用。此外，植物多肽如脂质转移蛋白、类橡胶素肽、硫堇、防御素和蛇形蛋白通过直接抗菌作用和系统抗性显著增强植物免疫力。分离技术、多组学方法、生物信息学和人工智能等技术进步加速了肽的发现。然而，在功能表征、肽稳定性、生产成本和生态影响方面仍然存在挑战。通过跨学科研究与合作解决这些问题将促进肽在农业和医学中的实际应用。
