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Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.测定口服泊沙康唑 12 或 24 周 4 种方案治疗甲真菌病成人患者的趾甲中泊沙康唑浓度。
Antimicrob Agents Chemother. 2011 Sep;55(9):4424-6. doi: 10.1128/AAC.01302-10. Epub 2011 Jul 11.
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A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis.一项多中心、随机、安慰剂和阳性对照、平行分组、研究者设盲的研究，评估了泊沙康唑四种治疗方案用于治疗成人趾甲甲真菌病的疗效。
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Pharmacokinetics and Pharmacodynamics of Posaconazole.泊沙康唑的药代动力学和药效学。
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本文引用的文献

1
Skin concentrations and pharmacokinetics of posaconazole after oral administration.口服泊沙康唑后的皮肤浓度和药代动力学。
Antimicrob Agents Chemother. 2010 May;54(5):1807-10. doi: 10.1128/AAC.01616-09. Epub 2010 Mar 1.
2
A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma.一种用于测定人血浆中泊沙康唑的灵敏液相色谱-质谱联用方法。
J Pharm Biomed Anal. 2007 Jan 4;43(1):228-36. doi: 10.1016/j.jpba.2006.06.011. Epub 2006 Jul 21.
3
In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.泊沙康唑、雷夫康唑、特比萘芬、伊曲康唑和氟康唑对皮肤癣菌、酵母菌及非皮肤癣菌属的体外活性。
Med Mycol. 2005 Mar;43(2):179-85. doi: 10.1080/13693780410001731583.
4
Pharmacokinetics of antifungal agents in onychomycoses.抗真菌药物在甲癣中的药代动力学。
Clin Pharmacokinet. 2001;40(6):441-72. doi: 10.2165/00003088-200140060-00005.
5
Determination of terbinafine in nail samples during systemic treatment for onychomycoses.
Br J Dermatol. 1990 Oct;123(4):481-6. doi: 10.1111/j.1365-2133.1990.tb01453.x.
6
Itraconazole penetrates the nail via the nail matrix and the nail bed--an investigation in onychomycosis.伊曲康唑通过甲母质和甲床渗透入指甲——一项关于甲癣的研究。
Clin Exp Dermatol. 1991 Sep;16(5):374-6. doi: 10.1111/j.1365-2230.1991.tb00405.x.
7
Posttreatment itraconazole levels in the nail. New implications for treatment in onychomycosis.
J Am Acad Dermatol. 1992 May;26(5 Pt 1):731-5. doi: 10.1016/0190-9622(92)70102-l.

测定口服泊沙康唑 12 或 24 周 4 种方案治疗甲真菌病成人患者的趾甲中泊沙康唑浓度。

Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.

机构信息

Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4424-6. doi: 10.1128/AAC.01302-10. Epub 2011 Jul 11.

DOI:10.1128/AAC.01302-10
PMID:21746944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165322/
Abstract

Pharmacokinetic data from a randomized, parallel-group, multicenter study are presented. Adults with toenail onychomycosis (n = 146) received posaconazole (100 mg, 200 mg, or 400 mg) once daily (QD) for 24 weeks or 400 mg QD for 12 weeks. The posaconazole concentration in the great toenail exhibited a dose-related increase starting at week 2 for 24 weeks and a mean toenail-to-plasma concentration ratio of approximately 3:1 at the end of treatment for the 400-mg 24-week dose.

摘要

现将一项随机、平行分组、多中心研究的药代动力学数据呈现如下。患有趾甲甲真菌病的成年人（n = 146）接受泊沙康唑（100 mg、200 mg 或 400 mg）每日一次（QD）治疗 24 周或 400 mg QD 治疗 12 周。24 周时，大脚趾甲中的泊沙康唑浓度开始呈剂量相关性增加，400 mg 24 周剂量治疗结束时的平均趾甲-血浆浓度比约为 3:1。