Matthieu L, De Doncker P, Cauwenbergh G, Woestenborghs R, van de Velde V, Janssen P A, Dockx P
Department of Dermatology, University Hospital, Antwerp, Belgium.
Clin Exp Dermatol. 1991 Sep;16(5):374-6. doi: 10.1111/j.1365-2230.1991.tb00405.x.
Nail-matrix kinetics were studied in 21 patients (19 with onychomycosis, two with tinea corporis) as soon as taking itraconazole (Sporanox) 100 mg daily for up to 7 months. Itraconazole was detected in the distal nail as soon as 1 month after the start of therapy (42 ng/g in fingernails and 16 ng/g in toenails). During the course of treatment, this concentration rose and reached a mean of 160 ng/g in fingernail clippings and 197 ng/g in toenail clippings. Moreover, in fingernails of 12 out of 21 patients and in toenails of six out of 20 patients, itraconazole was detected in the distal nail clippings before full outgrowth of the fastest-growing nail. In most patients, itraconazole was detected in the distal nail clippings earlier than would be expected if the drug were incorporated only via the nail matrix, indicating that in addition to the nail matrix, a second route of penetration into the nail exists, i.e. the nail bed.
对21例患者（19例甲癣患者，2例体癣患者）进行了甲母质动力学研究，这些患者每日服用100mg伊曲康唑（斯皮仁诺），持续长达7个月。治疗开始后1个月，在远端指甲中就检测到了伊曲康唑（手指甲中为42ng/g，脚趾甲中为16ng/g）。在治疗过程中，该浓度升高，指甲剪屑中的平均浓度达到160ng/g，脚趾甲剪屑中的平均浓度达到197ng/g。此外，在21例患者中的12例手指甲以及20例患者中的6例脚趾甲中，在生长最快的指甲完全长出之前，就在远端指甲剪屑中检测到了伊曲康唑。在大多数患者中，在远端指甲剪屑中检测到伊曲康唑的时间比仅通过甲母质掺入药物时预期的时间要早，这表明除了甲母质外，还存在第二条药物渗透进入指甲的途径，即甲床。
