脂皮质蛋白I与外周型苯二氮䓬类结合位点的相互作用。
Interaction of lipocortin I with peripheral-type benzodiazepine binding sites.
作者信息
Mihara S, Sakata T, Fujimoto M
机构信息
Shionogi Research Laboratories, Shionogi & Co. Ltd., Osaka, Japan.
出版信息
Eur J Pharmacol. 1990 Sep 18;189(2-3):233-6. doi: 10.1016/0922-4106(90)90028-v.
PMID:2174791
Abstract
Recombinant rat lipocortin I increased [3H]PK 11195 binding to porcine aortic smooth muscle membranes, whereas a polyclonal anti-rat lipocortin I antiserum decreased both basal and lipocortin I-enhanced [3H]PK 11195 binding. The results suggest the possibility of lipocortin I being involved in the function of peripheral-type benzodiazepine binding sites.
摘要
重组大鼠脂皮质蛋白I增加了[3H]PK 11195与猪主动脉平滑肌膜的结合，而多克隆抗大鼠脂皮质蛋白I抗血清则降低了基础及脂皮质蛋白I增强的[3H]PK 11195结合。这些结果提示脂皮质蛋白I可能参与外周型苯二氮䓬结合位点的功能。
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