Rastad Cecilia, Ulfberg Jan, Lindberg Per
Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden.
Depress Res Treat. 2011;2011:543906. doi: 10.1155/2011/543906. Epub 2011 Jun 13.
Objective. To investigate the effects of bright light treatment for secondary outcome measures and to explore and validate empirically derived subgroups and treatment effects in subgroups. Methods. A descriptive design. A sample of forty-nine persons (mean age of 45.8) with clinically assessed seasonal affective disorder (SAD) or subsyndromal SAD (S-SAD) participated in a two-group clinical trial evaluating the effects of treatment with bright light therapy. A person-oriented cluster analysis was applied to study treatment effects in subgroups. Results. For the merged group, sleepiness (Epworth Sleepiness Scale), fatigue (fatigue questionnaire), and health-related quality of life (SF-36) were improved at posttreatment, and results were maintained at the one-month followup. Three distinct subgroups had a high level of fatigue in common, while the level of excessive daytime sleepiness and depressed mood differed between the subgroups. Over time, all subgroups improved following ten days treatment in a light room. Conclusion. Fatigue, excessive daytime sleepiness, and health-related quality of life improve in a similar way as depressed mood following treatment with bright light. The treatment was effective irrespective of the severity of the disorder, that is, for persons with SAD and subsyndromal SAD.
目的。研究强光治疗对次要结局指标的影响，并探索和实证验证基于经验得出的亚组及亚组中的治疗效果。方法。描述性设计。四十九名经临床评估患有季节性情感障碍（SAD）或亚综合征性SAD（S-SAD）的人员（平均年龄45.8岁）参与了一项两组临床试验，评估强光疗法的治疗效果。采用以人为本的聚类分析来研究亚组中的治疗效果。结果。对于合并组，治疗后嗜睡（爱泼沃斯嗜睡量表）、疲劳（疲劳问卷）和健康相关生活质量（SF-36）得到改善，且结果在1个月随访时得以维持。三个不同的亚组都有较高的疲劳水平，而各亚组之间日间过度嗜睡和情绪低落的水平有所不同。随着时间推移，所有亚组在光照室接受十天治疗后均有改善。结论。强光治疗后，疲劳、日间过度嗜睡和健康相关生活质量的改善方式与情绪低落的改善方式相似。无论疾病严重程度如何，即对于患有SAD和亚综合征性SAD的人来说，该治疗都是有效的。
