一种简易、模块化且高产率的方法，用于组装三维 DNA 结构。
A facile, modular and high yield method to assemble three-dimensional DNA structures.
机构信息
Department of Chemistry, 801 Sherbrooke St. West, Montreal, QC, Canada H3A 2K6.
出版信息
Chem Commun (Camb). 2011 Aug 21;47(31):8925-7. doi: 10.1039/c1cc11726b. Epub 2011 Jul 11.
PMID:21748162
Abstract
We describe a rapid and quantitative method to generate DNA cages of deliberately designed geometry from readily available starting strands. Balancing the incorporation of sequence uniqueness and symmetry in a face-centered approach to 3D construction can result in triangular (TP), rectangular (RP), and pentagonal prisms (PP) without compromising the potential for nanostructure addressability.
摘要
我们描述了一种快速定量的方法，可从现成的起始链中生成具有故意设计的几何形状的 DNA 笼。在面心方法的 3D 构建中平衡序列独特性和对称性的结合，可以得到三角形 (TP)、矩形 (RP) 和五边形棱柱 (PP)，而不会影响纳米结构可寻址性的潜力。
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