Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, H3A 2K6 Canada.
Curr Opin Chem Biol. 2010 Oct;14(5):597-607. doi: 10.1016/j.cbpa.2010.08.002. Epub 2010 Sep 24.
A current challenge in nanoscience is to achieve controlled organization in three-dimensions, to provide tools for biophysics, molecular sensors, enzymatic cascades, drug delivery, tissue engineering, and device fabrication. DNA displays some of the most predictable and programmable interactions of any molecule, natural or synthetic. As a result, 3D-DNA nanostructures have emerged as promising tools for biology and materials science. In this review, strategies for 3D-DNA assembly are discussed. DNA cages, nanotubes, dendritic networks, and crystals are formed, with deliberate variation of their size, shape, persistence length, and porosities. They can exhibit dynamic character, allowing their selective switching with external stimuli. They can encapsulate and position materials into arbitrarily designed patterns, and show promise for numerous biological and materials applications.
当前纳米科学面临的一个挑战是在三维空间中实现可控组织，为生物物理学、分子传感器、酶级联反应、药物输送、组织工程和器件制造提供工具。DNA 显示出一些最可预测和可编程的相互作用，无论是天然的还是合成的。因此，3D-DNA 纳米结构已成为生物学和材料科学的有前途的工具。在这篇综述中，讨论了 3D-DNA 组装的策略。形成了 DNA 笼、纳米管、树枝状网络和晶体，其大小、形状、持久长度和孔隙率可以故意变化。它们可以表现出动态特征，允许它们在外力刺激下选择性切换。它们可以将材料封装并定位到任意设计的图案中，并在许多生物和材料应用中显示出前景。
