用于靶向肿瘤细胞治疗的适配体-药物偶联物

Aptamer-drug conjugation for targeted tumor cell therapy.

作者信息

Donovan Michael J, Meng Ling, Chen Tao, Zhang Yunfei, Sefah Kwame, Tan Weihong

机构信息

Department of Chemistry, Shands Cancer Center, Moffitt Cancer Center, Center for Research at Bio/Nano Interface, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

出版信息

Methods Mol Biol. 2011;764:141-52. doi: 10.1007/978-1-61779-188-8_9.

DOI:10.1007/978-1-61779-188-8_9

PMID:21748638

Abstract

Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance molecular imaging. Aptamers for these purposes are generated from SELEX (Systematic Evolution of Ligands by EXponential enrichment), more precisely cell-based SELEX, a process described in detail in this chapter. Experimental applications are also provided for aptamer-based drugs.

摘要

为癌症治疗应用开发的适配体可以提高药物治疗的疗效并增强分子成像。用于这些目的的适配体是通过指数富集配体系统进化技术（SELEX），更确切地说是基于细胞的SELEX生成的，本章将详细描述这一过程。还提供了基于适配体的药物的实验应用。