Association of chronic kidney disease and coronary artery disease in 1,010 consecutive patients undergoing coronary angiography.

BACKGROUND

Patients with chronic kidney disease (CKD) are more likely to have complications due to cardiovascular disease (CVD). This study was performed to investigate the prevalence of chronic kidney disease (CKD) and the relation of CKD and number of stenosed coronary vessels in patients who had undergone coronary angiography with suspected coronary artery disease (CAD).

METHODS

The data of 1,010 consecutive patients who underwent coronary angiography for suspected CAD in Zhongda Hospital were analyzed. Estimated glomerular filtration rate (eGFR) was calculated with the abbreviated Modified Diet in Renal Disease (MDRD) Study equation. CKD was defined as presence of eGFR <60 ml/min per 1.73 m(2) and/or proteinuria. Luminal narrowing with at least 1 lesion =50% in the main branches of the coronary artery was considered as CAD. The number of stenotic arteries was recorded (1- to 3-vessel disease [VD]). A significant stenosis in the left main trunk was scored as 2-VD.

RESULTS

Patients with CAD had a significantly higher prevalence of CKD compared with patients without CAD (18.8% vs. 5.4%, p<0.001). CKD was significantly associated with CAD, 2-VD and 3-VD, versus without CAD (0-VD) (odds ratio [OR] = 2.163; 95% confidence interval [95% CI], 1.296-3.611; OR=2.478; 95% CI, 1.288-4.766; OR=2.504; 95% CI, 1.271-4.933; respectively) after adjustment for covariates.

CONCLUSIONS

There was a higher prevalence of CKD in patients with CAD diagnosed by coronary angiography, and it increased with the number of stenosed coronary vessels. CKD is a critical risk factor for CAD, especially 3-VD.