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支架植入治疗先天性和复发性主动脉缩窄的结果 - 长达 13 年的随访。

Results of stent implantation for native and recurrent coarctation of the aorta-follow-up of up to 13 years.

机构信息

Department of Paediatric Cardiology, Evelina Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

出版信息

Catheter Cardiovasc Interv. 2011 Sep 1;78(3):405-12. doi: 10.1002/ccd.23023. Epub 2011 Jul 11.

Abstract

BACKGROUND

To evaluate the mid and long-term prognosis after stenting of native or recurrent CoA, we studied the cardiovascular parameters in the follow-up period up to 13 years.

METHODS AND RESULTS

Between 1993 and 2006, 68 patients underwent stent implantation for aortic coarctation (average age 25.5 years, range 5.7-65 years, average weight 65.5 kg, range 32-122 kg). Forty-six (68%) patients were aged >17 years. Stenting was performed for native coarctation in 41 and for recurrent coarctation in 27 patients, in 23 (34%) patients with a covered stent. Redilation was carried out in 26 (38%) patients. The invasive systolic gradient decreased from mean (±SD) 25 (±15) mm Hg to 5 (±5) mm Hg (P < 0.0005). The descending aorta pressure increased from 80 (±15) mm Hg to 101 (±18) mm Hg. The systolic right arm blood pressure decreased from a mean of 153 (±24) mm Hg to 129 (±18) mm Hg (P < 0.0005). Complications like small dissections were rare. Follow-up (6 days to 13 years, mean 41 months) was available in 66 patients, in 23 after reintervention at a mean of 71 months, range of 8 months to 10.3 years. Fifty-one percent remained clinically hypertensive.

CONCLUSIONS

Stenting of aortic coarctation gives good medium-term results. Frequent reintervention relate to deliberately under-dilating stents during the initial procedure. The reintervention rate has reduced since the introduction of covered stents.

摘要

背景

为了评估支架置入治疗先天性或复发性主动脉缩窄的中远期预后,我们对随访期内长达 13 年的心血管参数进行了研究。

方法和结果

1993 年至 2006 年间,68 例主动脉缩窄患者接受了支架植入术(平均年龄 25.5 岁,范围 5.7-65 岁,平均体重 65.5kg,范围 32-122kg)。46 例(68%)患者年龄>17 岁。支架置入治疗先天性主动脉缩窄 41 例,复发性主动脉缩窄 27 例,其中 23 例(34%)患者采用了覆膜支架。26 例(38%)患者进行了再扩张。有创收缩期梯度从平均(±SD)25(±15)mmHg 降至 5(±5)mmHg(P<0.0005)。降主动脉血压从 80(±15)mmHg 升至 101(±18)mmHg。收缩期右臂血压从平均 153(±24)mmHg 降至 129(±18)mmHg(P<0.0005)。小夹层等并发症罕见。66 例患者获得随访(6 天至 13 年,平均 41 个月),23 例患者在平均 71 个月(8 个月至 10.3 年)时再次介入。51%的患者仍有临床高血压。

结论

主动脉缩窄支架置入术可获得良好的中期结果。频繁的再次介入与初始手术中支架故意过度扩张有关。自覆膜支架引入以来,再次介入的发生率有所降低。

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