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儿童主动脉缩窄支架植入术的初步和 6 年结果。

Initial and six-year results of stent implantation for aortic coarctation in children.

机构信息

Department of Interventional Paediatric Cardiology, Iatrikon Medical Center, Athens, Greece.

出版信息

Am J Cardiol. 2012 May 15;109(10):1499-503. doi: 10.1016/j.amjcard.2012.01.365. Epub 2012 Feb 18.

DOI:10.1016/j.amjcard.2012.01.365
PMID:22342848
Abstract

Although stenting has been used as a treatment option for aortic coarctation (CoA) at increasingly younger ages, limited information is available on the long-term follow-up of stent implantation for CoA in pediatric patients. A total of 74 patients with CoA (mean age 8 ± 3 years) underwent stent implantation; 42 were treated for isolated native CoA and 32 for recurrent CoA. A total of 87 stents were implanted (bare metal stents in 71 patients and covered stents in 3 patients). Redilation of a previously implanted stent was performed in 32 patients. Immediately after stenting, the peak systolic pressure gradient decreased from 68 ± 16 mm Hg to 8 ± 5 mm Hg (p <0.05), and the CoA diameter increased from 5 ± 3 mm to 16 ± 3 mm (p <0.05). The most important procedural complication was aneurysm formation in 1 patient that was successfully treated with implantation of a covered stent. No early or late deaths occurred and no evidence was found of late aneurysm formation during a follow-up period of 6 years. Late stent fracture was observed in 3 patients. At the end of follow-up, no cases of recoarctation were identified on multislice computed tomography or magnetic resonance imaging, and 67 (85%) of the 74 patients were normotensive, receiving no medications. In conclusion, stent implantation is an effective and safe treatment alternative to conventional surgical management for the treatment of CoA in selected pediatric patients.

摘要

虽然支架置入术已被用作治疗主动脉缩窄(CoA)的一种选择,且年龄越来越小,但关于儿科患者 CoA 支架置入术的长期随访资料有限。共有 74 例 CoA 患者(平均年龄 8 ± 3 岁)接受了支架置入术;42 例为单纯原发性 CoA,32 例为复发性 CoA。共植入 87 枚支架(71 例患者植入裸金属支架,3 例患者植入覆膜支架)。32 例患者对先前植入的支架进行了再扩张。支架置入后即刻,收缩期峰值压力梯度从 68 ± 16mmHg 降至 8 ± 5mmHg(p <0.05),CoA 直径从 5 ± 3mm 增加至 16 ± 3mm(p <0.05)。最重要的手术并发症是 1 例患者出现动脉瘤形成,成功植入覆膜支架治疗。无早期或晚期死亡病例,随访 6 年未见晚期动脉瘤形成。3 例患者出现晚期支架断裂。随访结束时,多层螺旋 CT 或磁共振成像均未发现再狭窄病例,74 例患者中 67 例(85%)血压正常,无需服药。总之,支架置入术是一种有效且安全的治疗选择,可替代传统的手术治疗方法,用于治疗选定的儿科患者的 CoA。

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