Department of Psychological Medicine, University Malaya, Kuala Lumpur, Malaysia.
Acta Neurol Belg. 2011 Jun;111(2):155-6.
Somnambulism or sleepwalking is a sleep disorder of arousal. Compared to in adults, pediatric and adolescent sleep disorders is still under-researched and poorly described. We report the successful use of low dose quietiapine, an atypical antipsychotic, in the treatment of a 15-year-old Indian male who presented with significant somnambulism. To the best of our knowledge, this is the first report on the use of quetiapine for the treatment of somnambulism in the literature. The presence of high voltage delta waves in sleepwalkers has been offered as a possible explanation for the patho-physiology of sleepwalking Quetiapine has been reported to decrease brain delta activity, and we postulate that this may be the mechanism on how it was beneficial for our patient.
梦游症或睡行症是一种觉醒障碍。与成人相比，儿科和青少年睡眠障碍的研究仍较少，描述也较差。我们报告了使用低剂量喹硫平（一种非典型抗精神病药）成功治疗一名 15 岁印度男性的案例，该男性患有明显的梦游症。据我们所知，这是文献中首次报道喹硫平用于治疗梦游症。有人提出，梦游者睡眠中出现高电压德尔塔波可能是梦游症病理生理学的一种解释。有报道称喹硫平可降低大脑德尔塔活动，我们推测这可能是其对我们患者有效的机制。
