Rosebush Molly S, Rao Shailaja Kishan, Samant Sandeep, Gu Weikuan, Handorf Charles R, Pfeffer Lawrence M, Nosrat Christopher A
Department of Biologic and Diagnostic, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
J Tenn Dent Assoc. 2011 Spring;91(2):24-7; quiz 28-9.
Oral cancer is arguably the most serious condition that dental providers may encounter in their practice. The relatively poor prognosis associated with oral cancer highlights the importance of the dental team's awareness of the disease. While many characteristics of oral cancer have endured over time, new research is revealing trends that are changing the way we approach its screening, diagnosis and treatment. In this report, we provide a translational overview of oral cancer, including risk factors, signs and symptoms, clinical management, as well as our recent findings on the role of chronic inflammation in the development of the disease. In addition, our recent genetic profiling approach in both cancer cell lines and in patients has identified potential biomarkers, molecular pathways and therapeutic drugs (Velcade and Aspirin) for oral squamous cell carcinomas. This comprehensive review should be of interest to all dental professionals.
口腔癌可以说是牙科从业者在其临床实践中可能遇到的最严重病症。与口腔癌相关的相对较差的预后凸显了牙科团队对该疾病保持警觉的重要性。虽然口腔癌的许多特征长期以来一直存在，但新的研究正在揭示一些趋势，这些趋势正在改变我们对其筛查、诊断和治疗的方式。在本报告中，我们提供了口腔癌的转化性概述，包括风险因素、体征和症状、临床管理，以及我们最近关于慢性炎症在该疾病发展中作用的研究结果。此外，我们最近在癌细胞系和患者中采用的基因谱分析方法已经确定了口腔鳞状细胞癌的潜在生物标志物、分子途径和治疗药物（万珂和阿司匹林）。这篇全面的综述应该会引起所有牙科专业人员的兴趣。
