Department of Genetics, UCL Institute of Ophthalmology 11-43 Bath Street, London EC1V 9EL, UK.
Regen Med. 2011 Jul;6(4):469-79. doi: 10.2217/rme.11.37.
The discovery of methods to produce pluripotent stem cells from human skin cells and other adult tissues has created a new era in stem cell research. In this article, we discuss the generation and use of pluripotent stem cells for the study of retinal disorders and the development of cell-based therapies. We describe advances in protocols for differentiating pluripotent cells into photoreceptor precursors that might be suitable for transplantation and discuss the use of human induced pluripotent stem cell-derived photoreceptors for disease modeling and drug screening.
从人类皮肤细胞和其他成人组织中产生多能干细胞的方法的发现，开创了干细胞研究的新纪元。本文讨论了多能干细胞在视网膜疾病研究和细胞治疗开发中的应用。我们描述了将多能细胞分化为光感受器前体细胞的方案的进展，这些前体细胞可能适合移植，并讨论了使用人诱导多能干细胞衍生的光感受器进行疾病建模和药物筛选的应用。
