Ziegler M G, Morrissey E C, Kennedy B, Elayan H
Department of Medicine, University of California San Diego Medical Center 92103.
J Hypertens. 1990 Oct;8(10):927-31. doi: 10.1097/00004872-199010000-00007.
When a human kidney is transplanted, sympathetic nerves to that kidney are cut. We infused 3H-noradrenaline and then measured noradrenaline, dopamine and 3H-noradrenaline levels in the plasma and urine of renal transplant recipients and uninephrectomized control subjects. Less than 10% of 3H-noradrenaline cleared from the plasma appeared in the urine. Noradrenaline and dopamine appeared in the urine of transplant recipients at one-third the rate of control subjects, even though 3H-noradrenaline levels were slightly higher in the urine of transplant recipients. Transplant patients had a noradrenaline clearance of 128 +/- 50 ml/min, compatible with simple glomerular filtration, while controls had a higher calculated clearance of 229 +/- 41 ml/min. Plasma dopamine levels were very low compared with urinary dopamine. These results suggest that two-thirds of renal noradrenaline and dopamine depend on the presence of renal nerves. Almost all urinary dopamine comes from the kidney. For noradrenaline, urinary excretion is a very minor pathway for clearance from the plasma.
当进行人肾移植时，会切断移植肾的交感神经。我们注入了³H - 去甲肾上腺素，然后测量了肾移植受者和单侧肾切除对照受试者血浆和尿液中的去甲肾上腺素、多巴胺以及³H - 去甲肾上腺素水平。从血浆中清除的³H - 去甲肾上腺素不到10%出现在尿液中。尽管移植受者尿液中的³H - 去甲肾上腺素水平略高，但移植受者尿液中去甲肾上腺素和多巴胺的出现速率仅为对照受试者的三分之一。移植患者的去甲肾上腺素清除率为128±50毫升/分钟，与单纯肾小球滤过相符，而对照组的计算清除率更高，为229±41毫升/分钟。与尿多巴胺相比，血浆多巴胺水平非常低。这些结果表明，肾内三分之二的去甲肾上腺素和多巴胺依赖于肾神经的存在。几乎所有的尿多巴胺都来自肾脏。对于去甲肾上腺素而言，尿液排泄是其从血浆中清除的一条非常次要的途径。
