Department of Obstetrics & Gynecology, American University of Beirut-Medical Center, Beirut, Lebanon.
Am J Reprod Immunol. 2011 Sep;66(3):163-9. doi: 10.1111/j.1600-0897.2011.01052.x. Epub 2011 Jul 12.
Ghazeeri G, Abdullah L, Abbas O. Immunological differences in women compared with men: overview and contributing factors. Am J Reprod Immunol 2011; 66: 163-169 Gender differences in the innate and adaptive immune systems have long been observed in humans. These immunological differences in immune function manifest as diverse susceptibilities to different types of infections and varied risks of developing autoimmune disorders and maybe even, cancers. Several factors contribute to the development of this immunological dimorphism including sex hormones, genetic makeup, environmental causes, and more recently microchimerism. Although the aim behind this sexual immune dimorphism is still unclear, it is tempting to believe that the higher risk of developing autoimmune diseases in women somehow serves the higher evolutionary goal of reproduction and creating new life.
Ghazeeri G、Abdullah L 和 Abbas O 在《美国生殖免疫学杂志》2011 年发表的综述中提到，与男性相比，女性在免疫方面存在差异：免疫的性别差异 在人类的先天和适应性免疫系统中早已被观察到。这些免疫功能的免疫学差异表现为对不同类型感染的不同易感性，以及自身免疫性疾病和癌症发展风险的差异。导致这种免疫二态性的因素包括性激素、遗传因素、环境因素，以及最近的微嵌合体。尽管这种性免疫二态性的目的尚不清楚，但人们不禁相信，女性患自身免疫性疾病的风险更高，在某种程度上是为了更高的进化目标——生殖和创造新生命。
