Miyajima Y, Fukuda M, Kojima S, Matuyama K
Division of Hematology/Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital.
Rinsho Ketsueki. 1990 Oct;31(10):1670-3.
In seventeen (38.6%) out of forty-four children underwent bone marrow transplantation, transient fever with abnormal liver function tests occurred between 30 and 70 days following bone marrow transplantation. More than half of cases suffered from nausea, anorexia and general malaise. C reactive protein was negative in all but one case, and thrombocytopenia occurred in five cases. Transient fever with abnormal liver function tests occurred more frequently in patients with cytomegalovirus (CMV) infection (63.4%) than in patients without CMV infection (16.0%) (P less than 0.01). Therefore, CMV infection was considered to be the cause of transient fever with abnormal liver function tests. The incidence of transient fever with abnormal liver function tests was not significantly different between the patients with pretransplant positive anti-CMV titer and the patients with pretransplant negative anti-CMV titer. Clinical symptoms improved in 16 patients (93.4%), but fatal CMV interstitial pneumonia followed in one case.
44名儿童中有17名（38.6%）接受了骨髓移植，骨髓移植后30至70天出现了伴有肝功能检查异常的短暂发热。超过半数的病例出现恶心、厌食和全身不适。除1例病例外，所有病例的C反应蛋白均为阴性，5例出现血小板减少。伴有肝功能检查异常的短暂发热在巨细胞病毒（CMV）感染患者中（63.4%）比无CMV感染患者中（16.0%）更频繁出现（P小于0.01）。因此，CMV感染被认为是伴有肝功能检查异常的短暂发热的原因。移植前抗CMV滴度阳性的患者与移植前抗CMV滴度阴性的患者之间，伴有肝功能检查异常的短暂发热的发生率无显著差异。16例患者（93.4%）临床症状改善，但有1例随后发生致命的CMV间质性肺炎。
