血浆的质子核磁共振与癌症检测

The proton NMR of blood plasma and the test for cancer.

作者信息

Herring F G, Phillips P S, Pritchard H, Silver H, Whittal K P

机构信息

Department of Chemistry, University of British Columbia, Vancouver, Canada.

出版信息

Magn Reson Med. 1990 Oct;16(1):35-48. doi: 10.1002/mrm.1910160105.

DOI:10.1002/mrm.1910160105

PMID:2175009

Abstract

The water-suppressed proton NMR spectra of plasma from healthy controls and cancer patients have been recorded along with the high-density lipoprotein (HDL) and triglyceride (TG) levels in the plasma. The dependence of the average of methylene and methyl resonance linewidths on the HDL/TG ratio is demonstrated. It is shown that the deranged lipoprotein levels caused by the presence of cancer lead to the serological test for cancer proposed by Fossel. The work provides the formation for a complete understanding of the proposed serological test for cancer. However, the wide variation in lipoprotein composition in the plasma from both healthy adults and cancer patients means that the serological test proposed by Fossel cannot be used as a screen for cancer.

摘要

已记录了健康对照者和癌症患者血浆的水抑制质子核磁共振谱，以及血浆中的高密度脂蛋白（HDL）和甘油三酯（TG）水平。证明了亚甲基和甲基共振线宽的平均值对HDL/TG比值的依赖性。结果表明，癌症的存在导致脂蛋白水平紊乱，从而引出了福塞尔提出的癌症血清学检测方法。这项工作为全面理解所提出的癌症血清学检测方法提供了依据。然而，健康成年人和癌症患者血浆中脂蛋白组成的广泛差异意味着福塞尔提出的血清学检测方法不能用作癌症筛查。