Verdery R B, Benham D F, McLennan I, Busby M J, Wehrle J P, Glickson J D
Bowman Gray School of Medicine, Section on Internal Medicine and Gerontology, Winston-Salem, NC 27103.
Biochim Biophys Acta. 1989 Dec 18;1006(3):287-90. doi: 10.1016/0005-2760(89)90015-5.
Narrow proton nuclear magnetic resonance (1H-NMR) linewidths from plasma have been associated with the presence of malignancy (Fossel et al., New Engl. J. Med. (1986) 315, 1369-1376). In that study, subjects and controls were not fasted. In the present study, 1H-NMR methyl and methylene linewidths were measured in plasma from normolipemic individuals without cancer both during fasting and every 90 min after eating a fat meal. Plasma lipoprotein levels were measured in order to relate results to postprandial lipemia. Methyl, methylene, and average 1H-NMR linewidths were strongly positively correlated with high-density lipoprotein levels and inversely correlated with triacylglycerol-rich lipoprotein levels in both the fasting and postprandial states. Linewidths decreased postprandially, reaching a nadir at the peak of plasma triacylglycerol levels. This study demonstrated that postprandial lipemia can lead to narrowing of plasma methyl and methylene resonances comparable to that reported for subjects with cancer.
血浆中狭窄的质子核磁共振（1H-NMR）线宽与恶性肿瘤的存在有关（福塞尔等人，《新英格兰医学杂志》（1986年）315卷，1369 - 1376页）。在该研究中，受试者和对照组未禁食。在本研究中，对无癌症的血脂正常个体在禁食期间以及进食高脂餐后每90分钟采集的血浆进行1H-NMR甲基和亚甲基线宽测量。测量血浆脂蛋白水平以便将结果与餐后血脂相联系。在禁食和餐后状态下，甲基、亚甲基以及平均1H-NMR线宽均与高密度脂蛋白水平呈强正相关，与富含三酰甘油的脂蛋白水平呈负相关。线宽在餐后降低，在血浆三酰甘油水平峰值时达到最低点。本研究表明，餐后血脂可导致血浆甲基和亚甲基共振变窄，这与癌症患者报道的情况相当。
