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纯合子家族性高胆固醇血症患者主动脉瓣和二尖瓣狭窄的成功外科治疗:一例报告

Successful surgical management for aortic and mitral stenosis in homozygous familial hypercholesterolemia: a case report.

作者信息

Morimoto Naoto, Okada Kenji, Okita Yutaka

机构信息

Department of Cardiovascular Surgery, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0013, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2011 Jul;59(7):491-4. doi: 10.1007/s11748-010-0723-7. Epub 2011 Jul 14.

DOI:10.1007/s11748-010-0723-7
PMID:21751111
Abstract

A 72-year-old woman with a known history of homozygous familial hyperlipidemia (IIa) was referred to our hospital for an operation necessitated by aortic and mitral stenosis and paroxysmal atrial fibrillation. Computed tomography and cardiac catheterization revealed a heavily calcified aortic root and mitral annulus as well as a high-grade stenosis of the left anterior descending and right coronary arteries. Double aortic and mitral valve replacement concomitant with replacement of ascending aorta, maze III procedure, and coronary artery bypass were performed. Temporary hypothermic arrest was employed to reduce the risk of cerebral emboli.

摘要

一名72岁女性,有纯合子家族性高脂血症(IIa型)病史,因主动脉和二尖瓣狭窄以及阵发性心房颤动而需手术,遂转诊至我院。计算机断层扫描和心导管检查显示主动脉根部和二尖瓣环严重钙化,以及左前降支和右冠状动脉高度狭窄。进行了主动脉和二尖瓣双瓣置换术,同时置换升主动脉,迷宫III手术和冠状动脉搭桥术。采用了短暂低温停循环以降低脑栓塞风险。

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本文引用的文献

1
Aortic and mitral valve replacement with reconstruction of the intervalvular fibrous body in familial hypercholesterolemia.家族性高胆固醇血症患者行主动脉瓣和二尖瓣置换并重建瓣间纤维体
Thorac Cardiovasc Surg. 2009 Aug;57(5):303-4. doi: 10.1055/s-2008-1038697. Epub 2009 Jul 23.
2
Homograft replacement of the calcified aortic root in familial hypercholesterolemia.家族性高胆固醇血症中钙化主动脉根部的同种异体移植置换术。
Ann Thorac Surg. 2006 Jan;81(1):e4-5. doi: 10.1016/j.athoracsur.2005.07.077.
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Surgery for calcific aortic root stenosis in homozygous familial hypercholesterolemia.纯合子家族性高胆固醇血症患者钙化性主动脉根部狭窄的手术治疗
Eur J Cardiothorac Surg. 2006 Jan;29(1):114-6. doi: 10.1016/j.ejcts.2005.11.001. Epub 2005 Dec 6.
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Eur J Cardiothorac Surg. 2000 Aug;18(2):249-50. doi: 10.1016/s1010-7940(00)00456-5.
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