Thompson G R, Barbir M, Okabayashi K, Trayner I, Larkin S
Department of Cardiology, Royal Postgraduate Medical School, London, United Kingdom.
Arteriosclerosis. 1989 Jan-Feb;9(1 Suppl):I152-7.
Twelve years' experience confirms that plasma exchange beneficially influences the course of homozygous familial hypercholesterolemia. Pilot studies with low density lipoprotein (LDL) apheresis using a dextran sulphate affinity column suggest that this procedure has advantages over plasma exchange, which it may eventually replace. Combination therapy with lovastatin and LDL apheresis is currently being assessed as a means of inducing regression of coronary lesions. Preliminary results of a pilot study in four patients with heterozygous familial hypercholesterolemia are encouraging.
十二年的经验证实，血浆置换对纯合子家族性高胆固醇血症的病程有有益影响。使用硫酸葡聚糖亲和柱进行低密度脂蛋白（LDL）单采的初步研究表明，该方法比血浆置换更具优势，最终可能会取代血浆置换。目前正在评估洛伐他汀与LDL单采的联合治疗作为诱导冠状动脉病变消退的一种方法。一项针对四名杂合子家族性高胆固醇血症患者的初步研究的初步结果令人鼓舞。
