Ezrin 和 c-Met 蛋白的表达上调与胃癌的转移和预后相关。
Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas.
机构信息
Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, No 1 Hospital of China Medical University, Shenyang, Liaoning Province, China.
出版信息
Histol Histopathol. 2011 Sep;26(9):1111-20. doi: 10.14670/HH-26.1111.
Recent publications demonstrated that abnormal expression of Ezrin and c-Met proteins were related to carcinogenesis, metastasis and prognosis of various sorts of tumors. In this study we detected the expressions of Ezrin and c-Met proteins in normal gastric mucosa, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma and analyzed the correlations with metastasis and prognosis of gastric carcinomas. The results demonstrated that both Ezrin and c-Met overexpression were related to the occurrence and progression of gastric carcinoma. Our findings also demonstrated that combined detection of these two tumor-specific biomarkers in gastric carcinomas can provide additional efficacy in predicting the patients' outcomes.
最近的出版物表明，Ezrin 和 c-Met 蛋白的异常表达与各种肿瘤的癌变、转移和预后有关。在本研究中，我们检测了 Ezrin 和 c-Met 蛋白在正常胃黏膜、慢性萎缩性胃炎、肠上皮化生、异型增生和胃癌中的表达，并分析了它们与胃癌转移和预后的相关性。结果表明，Ezrin 和 c-Met 的过度表达均与胃癌的发生和进展有关。我们的研究结果还表明，联合检测这两种肿瘤特异性生物标志物在胃癌中的表达可以为预测患者的预后提供额外的疗效。
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