Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China.
J Cell Biochem. 2011 Nov;112(11):3079-84. doi: 10.1002/jcb.23262.
LuxR is a widespread and functional diverse transcription factors and belongs to TetR protein superfamily. It could both activate and inhibit the expression of many genes contingent on the contexts, thereby involving in many crucial physiological events, such as virulence factors production, biofilm formation, quorum sensing (QS), acetate metabolism, motility, bioluminescence, and ecological competition. We summarized the function diversity of LuxR and underlying mechanisms. The interchangeability of some transcriptional factors for secondary metabolites biosynthesis opens new avenue to obtain new chemical entities or higher yield of antibiotics via the manipulation of regulators instead of structural genes. Inhibitors of pathogen QS are under intensive screening for better new antibiotics against the drug resistance. A compendium of compounds capable of inhibiting LuxR family transcriptional factors is also presented.
LuxR 是一种广泛存在且功能多样的转录因子，属于 TetR 蛋白超家族。它可以根据环境激活和抑制许多基因的表达，从而参与许多关键的生理事件，如毒力因子的产生、生物膜的形成、群体感应（QS）、乙酸盐代谢、运动性、生物发光和生态竞争。我们总结了 LuxR 的功能多样性及其潜在的机制。一些转录因子在次生代谢物生物合成中的可互换性为通过操纵调节剂而不是结构基因来获得新的化学实体或提高抗生素产量开辟了新的途径。针对耐药性，人们正在积极筛选病原菌 QS 的抑制剂，以获得更好的新型抗生素。本文还介绍了能够抑制 LuxR 家族转录因子的化合物的概要。
