Egawa K, Inaba Y, Ono T, Arao T
Department of Dermatology, Kumamoto (Japan) University Medical School.
Arch Dermatol. 1990 Dec;126(12):1599-603. doi: 10.1001/archderm.126.12.1599.
Fourteen cases of plantar epidermoid cyst were studied immunohistochemically and five of them were also studied electron microscopically for the presence of human papillomavirus. In eleven cases, the test results were positive for papillomavirus antigens, and in five of them, papillomaviruslike particles were observed by electron microscopy. Histological examination showed most of the cysts to contain intracytoplasmic eosinophilic bodies in cells of the cyst wall as well as the vacuolar structures in the keratinous mass within the cavity. These findings suggest an etiologic association between the papillomavirus and plantar epidermoid cysts. The "cystic papilloma" produced in rabbits by the Shope papillomavirus has been clearly demonstrated. We propose that human papillomaviruses play an important role in the genesis of plantar epidermoid cysts. This is the first report on the possible existence of a cystic papilloma in humans.
对14例足底表皮样囊肿进行了免疫组织化学研究，其中5例还进行了电子显微镜检查以检测人乳头瘤病毒的存在。11例检测结果显示乳头瘤病毒抗原呈阳性，其中5例通过电子显微镜观察到乳头瘤病毒样颗粒。组织学检查显示，大多数囊肿在囊壁细胞中含有胞质内嗜酸性小体，以及腔内角质块中的空泡结构。这些发现提示乳头瘤病毒与足底表皮样囊肿之间存在病因学关联。由肖普乳头瘤病毒在兔体内产生的“囊性乳头瘤”已得到明确证实。我们认为人乳头瘤病毒在足底表皮样囊肿的发生中起重要作用。这是关于人类可能存在囊性乳头瘤的首次报告。
