Puvanalingam A, Rajendiran C, Sivasubramanian K, Ragunanthanan S, Suresh Sarada, Gopalakrishnan S
Institute of Internal Medicine, Madras Medical College, Chennai-600003.
J Assoc Physicians India. 2011 Jan;59:14-6, 18.
To study the clinical profile of the H1N1 influenza cases attending government hospitals in South India and to study the impact of H1N1 infection on pregnancy outcome.
A total number of 442 H1N1 positive patients (198 inpatients and 244 outpatients) from two government hospitals in Chennai, Madras Medical College & Government General Hospital and Institute of Child Health, Egmore were studied retrospectively during a period of 6 months from August 2009 to January 2010.
The rate of reported cases and hospitalization rates was highest among individuals aged 5 to 24 years. H1N1 cases were equally distributed in both the sexes in the adult population In our study 86.92% percent of patients with pandemic H1N1 influenza A met the case definition for influenza like illness (subjective fever plus cough and/or sorethroat). Similar to the western data bronchial asthma, pulmonary tuberculosis were found to risk factors for complications in H1N1 infection. The overall mortality rate was 1.8% and the most common cause of death in patients was due to pneumonia. Ventilator requirement was associated with poor prognosis in H1N1 patients. P value < 0.01. The percentage of persons > 65 years who were affected was far less ie 0.67% which is quite unusual in the case of seasonal flu. H1N1 pnuemonia was found to involve predominantly the lower lobe of lung. (p value < 0.01).The mortality rate among pregnant women with H1N1 infection was 25% and the fetal loss rate was 16.67%. There was an increased risk of H1N1 influenza infection during the third trimester of pregnancy. (p value-0.027).
Individuals with comorbid conditions, pregnancy were found to be severely affected. Hence individuals with risk factors need to be protected by vaccination.
研究印度南部政府医院收治的甲型H1N1流感病例的临床特征，并研究甲型H1N1流感感染对妊娠结局的影响。
回顾性研究了2009年8月至2010年1月期间来自金奈的两家政府医院（马德拉斯医学院和政府总医院以及埃格莫尔儿童健康研究所）的442例甲型H1N1流感阳性患者（198例住院患者和244例门诊患者）。
报告病例率和住院率在5至24岁人群中最高。在成人人群中，甲型H1N1流感病例在男女中分布均匀。在我们的研究中，86.92%的甲型H1N1大流行性流感患者符合流感样疾病的病例定义（主观发热加咳嗽和/或喉咙痛）。与西方数据相似，支气管哮喘、肺结核被发现是甲型H1N1感染并发症的危险因素。总死亡率为1.8%，患者最常见的死亡原因是肺炎。甲型H1N1患者使用呼吸机与预后不良相关。P值<0.01。65岁以上受影响人群的比例极低，仅为0.67%，这在季节性流感中非常罕见。甲型H1N1肺炎主要累及肺下叶。（P值<0.01）。甲型H1N1感染孕妇的死亡率为25%，胎儿丢失率为16.67%。妊娠晚期甲型H1N1流感感染风险增加。（P值-0.027）。
发现患有合并症、妊娠的个体受到严重影响。因此，有危险因素的个体需要通过接种疫苗来保护。
