State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
J Org Chem. 2011 Aug 19;76(16):6918-24. doi: 10.1021/jo201111w. Epub 2011 Jul 26.
An efficient strategy for the total synthesis of (+)-przewalskin B is reported. The key steps feature an intermolecular S(N)2' substitution of iodoallylic phosphate with organocupper reagent, a diastereoselective organocatalytic aldol cyclization, as well as a Rh(2)(OAc)(4)-mediated intramolecular carbene insertion to the tertiary C-H bond.
报道了（+）-升麻素 B 的全合成的有效策略。关键步骤包括碘烯丙基磷酸盐与有机铜试剂的分子间 S(N)2'取代、立体选择性有机催化Aldol 环化，以及 Rh(2)(OAc)(4)介导的三级 C-H 键的分子内卡宾插入。
